Claim C-0004

In infants with moderate atopic dermatitis, a single cohort suggests that long-term exposure to particulate matter below 10 µm (PM₁₀) makes the disease more likely to persist to the age of three; in the whole cohort no association was found.

Structure

Factor: Particulate matter (PM₂.₅ and PM₁₀)
Outcome: Atopic dermatitis (eczema)
Population: infants with atopic dermatitis, followed to the age of three
Relation: increases · hazard ratio 1.19 (95 % CI 1.05–1.36) per 1 µg/m³ in the moderate subgroup
Evidence grade: D · single-study
Caveat: a subgroup result from one cohort of 150 children in Seoul; the overall result of the same cohort was not significant; a subgroup result, stratified by baseline severity; the primary analysis of the same cohort found no significant association (F-0009)

Based on

Finding F-0010: “However, when stratified by the baseline AD severity, increased exposure to PM10 significantly elevated the risk of persistence in children with moderate AD at enrollment (HR, 1.19; 95% CI, 1.05−1.36; P = 0.007).” (CKB 1467, p. 1)

Counter-evidence

Finding F-0009: “Overall, long-term exposure to PM10 was not significantly associated with AD persistence at age 3 (hazard ratio [HR], 1.04; 95% confidence interval [CI], 0.97−1.12; P = 0.267 per 1 μg/m3).” (CKB 1467, p. 1)

A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.