Claim · according to Coridum · status superseded
Claim C-0005
In children, higher indoor exposure to volatile organic compounds is associated with more severe atopic dermatitis; the size of the effect is uncertain, because the confidence intervals of the panel study include zero.
Structure
- Factor
- Volatile organic compounds (VOCs)
- Outcome
- Atopic dermatitis (eczema)
- Population
- children
- Relation
- increases · symptoms rose by 12.7 % two days after each 1 ppb of indoor toluene; adjusted odds ratios 3.52 and 3.77 for urinary metabolites of toluene and of styrene and ethylbenzene
- Evidence grade
- B · consistent
- Caveat
- two of the four Findings have confidence intervals that include zero; exposure in the cross-sectional studies is measured through urinary metabolites, not through indoor air
Based on
- Finding F-0005: “An increased concentration of benzene by 1 ppb was associated with a 12.0% (95% CI: -0.9 to 26.6) increase in AD symptoms, although statistical significance was borderline (P = 0.07).” (CKB 0608, p. 6)
- Finding F-0006: “When the delayed effect of indoor air pollutants on AD symptoms 2 days later was evaluated, AD symptoms significantly increased by 12.7% (95% CI: -0.01 to 27.1) as indoor levels of toluene increased by 1 ppb (P = 0.05).” (CKB 0608, p. 6)
- Finding F-0007: “The results indicated that benzylmercapturic acid was more common in children with atopic dermatitis (19.5% vs. 13.5%, P = 0.005), consistent with the results of the multivariate analysis for this compound (adjusted odds ratio [aOR], 3.52; 95% confidence interval [CI], 1.34–8.94; P = 0.008).” (CKB 0634, p. 4)
- Finding F-0021: “Comparison of the first and fourth quartiles for mandelic acid indicated that atopic dermatitis was also associated with mandelic acid concentration (aOR, 3.77; 95% CI, 1.19–11.92; P = 0.024).” (CKB 0634, p. 4)
Counter-evidence
None found after an active search.
A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.