Claim · according to Coridum · status superseded
Claim C-0009
Removing indoor sources — a low pollutant room, low-emission wallpaper and flooring — appears to reduce the severity of atopic dermatitis in children.
Structure
- Outcome
- Atopic dermatitis (eczema)
- Intervention
- Source control
- Population
- children with moderate to severe atopic dermatitis
- Relation
- decreases · SCORAD index fell from 42.0 to 29.8 in a low pollutant room, and fell again on readmission from 53.1 to 39.2
- Evidence grade
- B · consistent
- Caveat
- all four Findings come from small unblinded studies in one country; in one of them the overall correlation between indoor air quality and severity was not significant, only the subgroup with the largest fall in formaldehyde improved more; the grade table would allow A (three class-3 documents), but the studies are not independent enough for it
Based on
- Finding F-0022: “Results: The SCORAD was significantly reduced from 42.0 ± 11 .5 to 29.8 ± 8.9 (p < 0.001) by management in a low pollutant room.” (CKB 0603, p. 1)
- Finding F-0023: “Out of 29 patients in the aggravated group, 8 patients were readmitted to the low pollutant room, and their SCORAD indices rapidly decreased from 53.1 ± 16.2 to 39.2 ± 9.8 (p = 0.036).” (CKB 0603, p. 3)
- Finding F-0025
- Finding F-0026: “However, subjects whose indoor FA concentration decreased greater than the mean (−41.9 μg/m3) showed a greater reduction of EASI score (−2.69 vs. −1.48).” (CKB 0606, p. 3)
Counter-evidence
None found after an active search.
A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.