Claim · according to Coridum · status superseded
Claim C-0011
In children, higher indoor exposure to volatile organic compounds is associated with more severe symptoms of atopic dermatitis.
Structure
- Factor
- Volatile organic compounds (VOCs)
- Outcome
- Atopic dermatitis symptoms
- Population
- children with atopic dermatitis
- Relation
- increases · symptoms rose by 12.7 % two days after each 1 ppb of indoor toluene, and by 12.0 % per 1 ppb of benzene
- Evidence grade
- D · single-study
- Caveat
- one prospective panel study in a newly built day-care centre; both confidence intervals include zero, so the size is uncertain. A Claim about symptoms is never raised to a Claim about the disease - the disease is covered by the Claim on urinary metabolites
Based on
- Finding F-0005: “An increased concentration of benzene by 1 ppb was associated with a 12.0% (95% CI: -0.9 to 26.6) increase in AD symptoms, although statistical significance was borderline (P = 0.07).” (CKB 0608, p. 6)
- Finding F-0006: “When the delayed effect of indoor air pollutants on AD symptoms 2 days later was evaluated, AD symptoms significantly increased by 12.7% (95% CI: -0.01 to 27.1) as indoor levels of toluene increased by 1 ppb (P = 0.05).” (CKB 0608, p. 6)
Counter-evidence
None found after an active search.
A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.