Claim · according to Coridum · status published
Claim C-0012
In children, raised urinary metabolites of volatile organic compounds are more common in those with atopic dermatitis.
Structure
- Factor
- Volatile organic compounds (VOCs)
- Outcome
- Atopic dermatitis (eczema)
- Population
- children
- Relation
- increases · adjusted odds ratios 3.52 (95 % CI 1.34-8.94) for the toluene metabolite and 3.77 (95 % CI 1.19-11.92) for the styrene and ethylbenzene metabolite
- Evidence grade
- D · single-study
- Caveat
- one cross-sectional study of 149 children; exposure is measured in urine, not in indoor air, so the route and the level indoors are unknown
Based on
- Finding F-0007: “The results indicated that benzylmercapturic acid was more common in children with atopic dermatitis (19.5% vs. 13.5%, P = 0.005), consistent with the results of the multivariate analysis for this compound (adjusted odds ratio [aOR], 3.52; 95% confidence interval [CI], 1.34–8.94; P = 0.008).” (CKB 0634, p. 4)
- Finding F-0021: “Comparison of the first and fourth quartiles for mandelic acid indicated that atopic dermatitis was also associated with mandelic acid concentration (aOR, 3.77; 95% CI, 1.19–11.92; P = 0.024).” (CKB 0634, p. 4)
Counter-evidence
None found after an active search.
A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.