Claim C-0013

A single uncontrolled study suggests that admitting children with atopic dermatitis to a low-pollutant room for three to four days lowers the severity of their disease.

Structure

Outcome: Atopic dermatitis (eczema)
Intervention: Source control
Population: children with moderate to severe atopic dermatitis
Relation: decreases
Evidence grade: D · single-study
Caveat: both supports come from one study (CKB 0603) and are before-and-after comparisons with no control group; that same study found no statistically significant difference in the indoor environment between the children who relapsed after discharge and those who did not

Based on

Finding F-0022: “Results: The SCORAD was significantly reduced from 42.0 ± 11 .5 to 29.8 ± 8.9 (p < 0.001) by management in a low pollutant room.” (CKB 0603, p. 1)
Finding F-0023: “Out of 29 patients in the aggravated group, 8 patients were readmitted to the low pollutant room, and their SCORAD indices rapidly decreased from 53.1 ± 16.2 to 39.2 ± 9.8 (p = 0.036).” (CKB 0603, p. 3)

Counter-evidence

Finding F-0026: “However, subjects whose indoor FA concentration decreased greater than the mean (−41.9 μg/m3) showed a greater reduction of EASI score (−2.69 vs. −1.48).” (CKB 0606, p. 3)
Finding F-0027: “The decrease in the SCORAD was greater in the EF-wallpaper group than in the PVC-wallpaper group though of no statistical significance.” (CKB 0611, p. 8)

A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.