Claim · according to Coridum · status published
Claim C-0015
In children attending daycare, a single French study suggests that higher indoor concentrations of two solvents — methyl isobutyl ketone and 1-methoxy-2-propyl acetate — go together with recurrent wheeze; for two further compounds the association did not survive correction for multiple testing.
Structure
- Source
- Cleaning products, Personal care products, Renovation and redecoration
- Factor
- Volatile organic compounds (VOCs)
- Outcome
- Wheeze
- Population
- children in daycare
- Relation
- increases · odds ratio 2.4 to 2.6, highest against lowest quartile
- Evidence grade
- D · single-study
- Caveat
- one cross-sectional study, 532 children in 100 French daycares; exposure measured on a single day of active sampling, so it stands for the room rather than for the child's exposure over time; the outcome is wheeze reported by parents, not diagnosed asthma
Based on
- Finding F-0028: “After correction for multiple testing, higher concentrations of methylisobutylketone (Odds-Ratio for Q4 vs. Q1, 95%CI: 2.40, 1.46–3.92; p-trend < 0.001, FDR-adjusted p = 0.02) and 1-methoxy-2-propylacetate (2.58, 1.54–4.33; p-trend < 0.001, FDR-adjusted p = 0.02) were associated with recurrent wheeze.” (CKB 1230, p. 1)
- Finding F-0029: “After correction for multiple testing, higher concentrations of methylisobutylketone (Odds-Ratio for Q4 vs. Q1, 95%CI: 2.40, 1.46–3.92; p-trend < 0.001, FDR-adjusted p = 0.02) and 1-methoxy-2-propylacetate (2.58, 1.54–4.33; p-trend < 0.001, FDR-adjusted p = 0.02) were associated with recurrent wheeze.” (CKB 1230, p. 1)
- Finding F-0032: “For factor 3, which reflects indoor VOCs/aldehydes from cleaning products and personal care products / cosmetics, the ORs for all outcomes ranged from 1.15 to 1.22, with a significant association with ever wheeze with ICS (OR: 1.22; 95%CI 1.00-1.47).” (CKB 1230, p. 9)
- Finding F-0033: “For factor 4, related to construction or painting emissions, significant associations were observed for recurrent wheeze (OR: 1.31; 95%CI: 1.06–1.64) and ever wheeze with ICS (OR 1.26; 95%CI: 1.02–1.55).” (CKB 1230, p. 9)
- Finding F-0034: “For factor 4, related to construction or painting emissions, significant associations were observed for recurrent wheeze (OR: 1.31; 95%CI: 1.06–1.64) and ever wheeze with ICS (OR 1.26; 95%CI: 1.02–1.55).” (CKB 1230, p. 9)
Counter-evidence
- Finding F-0030: “Associations were further suggested for 1,2,4-trimethylbenzene (2.70, 1.34–5.45; p-trend = 0.01) and decamethylcyclopentasiloxane (2.27, 1.09–4.71; p-trend = 0.02) but were not significant after correction for multiple testing.” (CKB 1230, p. 1)
- Finding F-0031: “Associations were further suggested for 1,2,4-trimethylbenzene (2.70, 1.34–5.45; p-trend = 0.01) and decamethylcyclopentasiloxane (2.27, 1.09–4.71; p-trend = 0.02) but were not significant after correction for multiple testing.” (CKB 1230, p. 1)
A Claim is Coridum’s synthesis of Findings and Observations; the evidence grade follows the study designs behind it.