Finding F-0849

“Children with an episode of severe pneumonia had mean COHb of 5.24% (SD, 3.99%), and those with an episode that included low oxygen saturation had mean COHb of 4.03% (SD, 2.27%).”

PhD Pneumonia and Exposure to Household Air Pollution in Children Under the Age of 5 Years in Rural Malawi (2020). Chest. Page 5. CKB 7875

Structure

Source: Biomass fuel
Factor: Carbon monoxide (CO)
Outcome: Pneumonia
Population: children under 5 years
Setting: home, MW
Study design: longitudinal analysis inside the Cooking and Pneumonia Study, a cluster-randomised trial of cleaner-burning biomass cookstoves in rural Malawi: repeated 24-hour personal carbon monoxide (5521 measurements) and carboxyhaemoglobin (4065 measurements) in children under five against pneumonia episodes, with mixed models adjusted for time, age, sex and smokers in the household (class 3)
Effect: mean 4.03
Sample: 4065 measurements
Caveat: the sicker children had the lower biomarker, which is the inverse of what exposure would predict

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