Finding F-0909

“In exposure-response analyses, each 1ppm increase in CO exposure is associated with a 0.015 g/dL (95% CI: 0.008, 0.023) increase in hemoglobin.”

Sinharoy Effects of cooking with liquefied petroleum gas versus biomass on hemoglobin concentrations in pregnant women: a pre-specified exploratory analysis of the HAPIN trial (2026). Nat Commun. Page 1. CKB 1689

Structure

Factor: Carbon monoxide (CO)
Population: pregnant women
Setting: personal exposure of the pregnant woman
Study design: prespecified exploratory analysis of the HAPIN randomised trial in Guatemala, India, Peru and Rwanda: pregnant women were randomised to a liquefied petroleum gas stove and fuel or to their usual biomass stove, with 24-hour personal PM2.5, black carbon and carbon monoxide measured and haemoglobin measured during pregnancy; intention-to-treat and exposure-response mixed models (class 3)
Effect: beta 0.015 (0.008–0.023) per 1 ppm of 24-hour personal carbon monoxide g/dL
Caveat: the authors read it as the same physiology as in smokers, where inhaled carbon monoxide raises haemoglobin

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