Finding F-1685

“Increased endotoxin exposure (by quartile) showed protective effects for asthma in individuals with at least one copy of the minor allele (OR = 0.39 per quartile increase in endotoxin, 95% CI 0.15 to 1.01).”

Effects of endotoxin exposure on childhood asthma risk are modified by a genetic… (2011). BMC medical genetics. Page 1. CKB 2224

Structure

Factor: Endotoxin
Outcome: Asthma
Setting: home
Study design: gene-environment interaction analysis within two birth cohorts: early-life endotoxin exposure in house dust related to asthma and eczema by age 6, tested for interaction with candidate single nucleotide polymorphisms (class 4)
Effect: OR 0.39 (0.15–1.01) per 1 quartile
Caveat: only in the carriers of at least one copy of the minor allele of rs156265 in ACAA1; the interval touches 1, and the exposure is endotoxin measured in house dust

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